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Which patients will respond to melanoma immunotherapy?

Patients with metastatic melanoma who have benefited from a new type of cancer immunotherapy don’t appear to share the same tumor-produced antigens, according to a new report by Eliezer Van Allen and colleagues. If the molecular targets for the immunotherapy differ from patient to patient, as this study suggests, it may be difficult to predict [...]

Mathematical ‘Gingko trees’ reveal mutations in single cells that characterize diseases

Online app could help clinicians choose the best treatments by comparing genetic fingerprints of individual cells Seemingly similar cells often have significantly different genomes. This is often true of cancer cells, for example, which may differ one from another even within a small tumor sample, as genetic mutations within the cells spread in staccato-like bursts. [...]

Modified CAR T cells can preferentially target cancer cells and spare normal cells

Engineering chimeric antigen receptor (CAR) T cells to lower their affinity for the protein epithelial growth factor receptor (EGFR) made the cells preferentially recognize and eliminate tumor cells that have high amounts of EGFR while sparing normal cells that have lower amounts of the protein, according to a preclinical study. CAR T cells that are [...]

Inducing metabolic catastrophe in cancer cells

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Cancer cells survive the stressful environment inside a tumor in part through autophagy, the controlled digestion and recycling of damaged components. However, blocking the process doesn’t kill cancer cells, [...]

CNIO scientists propose attacking bioenergetic metabolism to improve anti-cancer therapies

Cancer cells become addicted to glucose, which they use as their regular source of energy to grow and develop. Although this was observed over nine decades ago by the German physiologist, Otto Warburg; there is still not therapeutic strategy today that can effectively take advantage of this special energy requirement. The initial approach appears to [...]