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Research on yeast leads to evidence in key process of chromosome length – Findings could shed light on cancer, aging

Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging. In a paper recently published as the cover story in the online journal eLife, biologist David C. Zappulla and graduate student Evan [...]

New study shows smoking doesn’t always mean a shortened life span or cancer

Smoking has been shown to have drastic consequences for lifespan and disease progression, and it has been suggested that cigarette exposure may impact the risk of death and disease via its acceleration of the aging process. Not all smokers experience early mortality, however, and a small proportion manage to survive to extreme ages. Using long-lived [...]

Nine-gene MPI can provide accurate survival stratification in patients with non-small cell lung cancer

A nine-gene molecular prognostic index (MPI) for patients with early-stage non-small cell lung cancer (NSCLC) was able to provide accurate survival stratification and could potentially inform the use of adjuvant therapy in patients struggling with the disease, according to a study published August 18 in the JNCI: Journal of the National Cancer Institute. Non-small cell [...]

Corrected protein structure reveals drug targets for cancer, neurodegenerative diseases

Study revises previously published structure of Protein Kinase C enzyme, proposes new strategies to turn the enzyme ‘on’ to treat cancer or ‘off’ to treat neurodegenerative diseases Study co-authors Corina Antal (left) and Julia Callender (right) are holding the pieces of a new PKC model. Credit: UC San Diego Health

Clinical scoring system suggests possibility of more precise colon cancer screening

A clinical scoring system for colon cancer risk could help physicians identify which average-risk patients could potentially skip a colonoscopy and instead be screened with a less-invasive method. The researchers suggest that this approach could increase the uptake and efficiency of colorectal cancer (CRC) screening. The cross-sectional study is published in Annals of Internal Medicine. [...]