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Prion protein protects against epilepsy

Neuroprotective role of PrPC confirmed with unprecedented accuracy This is the prion protein. Credit: G. Giachin & G. Legname (SISSA) __SOURCEFROM__ International School of Advanced Studies (SISSA)

Prion trials and tribulations: Finding the right tools and experimental models

Prions are fascinating, enigmatic, and might teach us not only about rare prion diseases like Creutzfeld-Jakob disease, mad cow disease, or scrapie, but also about other more common neurodgenerative diseases. Two studies published on July 2nd in PLOS Pathogens report progress with novel tools and paradigms to study prion disease. Prion protein, shown in red, [...]

Naturally occurring genetic variation gives complete resistance in prion diseases

Researchers at the Medical Research Council’s Prion Unit have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as Creutzfeldt-Jakob disease (CJD). The findings, published in Nature, could give important insight into other human brain diseases that lead to dementia. Prions are infectious agents that cause invariably [...]

Prion protein can trigger spongiform encephalopathy and neurodegeneration

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein. Notably, C-transmembrane form of prion protein and cytosolic prion protein can result in neurodegenerative diseases in cases of error location,aggregation tendency, failure of signal peptides, body stress or incomplete removal of topologic prion protein. Zhiqi Song [...]

Protective pathway identified to counter toxicity associated with Alzheimer’s disease

New research led by Marco Prado, PhD, of Western University has identified a pathway used by the brain to try to protect itself from toxicity that occurs with Alzheimer’s disease (AD). Prado and his colleagues at the Robarts Research Institute and at the A.C. Camargo Cancer Center in Brazil have done extensive work on the [...]