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Modulation of brain cholesterol: A new line of research in Alzheimer’s disease treatment?

We have known for some years that Alzheimer’s disease is characterised by two types of lesions, amyloid plaques and degenerated tau protein. Cholesterol plays an important role in the physiopathology of this disease. Two French research teams (Inserm/CEA/University of Lille/University of Paris-Sud ) have just shown, in a rodent model, that overexpressing an enzyme that [...]

Does heart disease begin in childhood?

Are the first signs that someone is at risk of developing cardiovascular disease detectable in toddlers and preschoolers? There’s evidence that low vitamin D levels in adults are linked to cardiovascular disease, as well as other health issues such as obesity, hypertension and diabetes. But that link hadn’t been studied in children. Researchers in Toronto [...]

CT angiography links arterial plaque with diabetes, blood pressure, cholesterol

Non-calcified arterial plaque is associated with diabetes, high systolic blood pressure and elevated ‘bad’ cholesterol levels in asymptomatic individuals, according to a new study published online in the journal Radiology. These images are from a 62-year-old man. Left: coronary segmentation model of the coronary tree. Middle: a curved multiplanar reconstruction of the left anterior descending [...]

Large-scale meta-analysis discovered 10 new genes that tune cholesterol levels

An international research consortium has discovered ten new genes underlying blood lipid levels. This large study, published in the world’s leading genetic journal, Nature Genetics, was led by researchers at the Institute for Molecular Medicine Finland and Medical Faculty, University of Helsinki. In this study the DNA of more than 60,000 individuals was examined to [...]

Enriched broccoli reduces cholesterol

Including a new broccoli variety in the diet reduces blood LDL-cholesterol levels by around 6%, according to the results of human trials led by the Institute of Food Research. The broccoli variety was bred to contain two to three times more of a naturally occurring compound glucoraphanin. It is now available in supermarkets, under the [...]