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Improving post-hospital outcomes with community health worker intervention

Hospitalized patients with low-socioeconomic status were more likely to obtain post-discharge primary care and less likely to have multiple 30-day readmissions to the hospital when they worked with community health workers to create individualized plans for their recovery goals, according to a study by Shreya Kangovi, M.D., M.S., of the University of Pennsylvania Perelman School [...]

A Promising Therapeutic Strategy For Muscular Dystrophy: Exon Skipping To Restore Gene Expression

A novel therapeutic approach called exon skipping involves bypassing a disease-causing mutation in a gene to restore normal gene expression and protein production. Two innovative examples of this strategy used to correct gene defects associated with muscular dystrophy are described in articles in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [...]

Preventing Rejection Of Disease-Fighting Proteins

The body’s natural reaction to reject replacement proteins represents a major obstacle to the successful use of gene therapy to cure a range of life-threatening diseases. A novel method that uses the body’s own immune cells to induce tolerance to a specific protein was shown to suppress the rejection response, as described in an article [...]

Levels Of Deficient Protein In Friedreich’s Ataxia boosted by New Gene Therapy Strategy

A novel approach to gene therapy that instructs a person’s own cells to produce more of a natural disease-fighting protein could offer a solution to treating many genetic disorders. The method was used to achieve a 2- to 3-fold increase in production of a protein deficient in patients with Friedreich’s ataxia, as described in an [...]

Vaccine Negates Effects Of Cocaine In Mice

A single-dose vaccine capable of providing immunity against the effects of cocaine offers a novel and groundbreaking strategy for treating cocaine addiction is described in an article published Instant Online in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc. The article is available free online at the Human Gene Therapy website.* “This [...]