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Scientists report success using zebrafish embryos to identify potential new diabetes drugs

New form of high throughput screening could significantly shorten drug discovery for many diseases, researchers say The pancreatic beta cells of a specially bred zebrafish glow yellow to indicate the production of insulin. The pancreatic cells not responsible for producing insulin glow red. Credit: Credit: Johns Hopkins Medicine

How thiazolidinediones work to improve glucose metabolism

A research team led by Brigham and Women’s Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has uncovered surprising new findings that underscore the role of an important signaling pathway, already known to be critical in cancer, in the development of type 2 diabetes. Their results, published in the advance online issue of the journal Nature, [...]

Light-activated drug could reduce side effects of diabetes medication

Scientists have created a drug for type 2 diabetes that is switched on by blue light, which they hope will improve treatment of the disease. Diabetes drugs that promote the release of insulin from the pancreas can in some cases cause side effects due to their actions on other organs such as the brain and [...]

Drug adherence boosted, health-care costs reduced by community pharmacist intervention

Community pharmacists can dramatically help their patients stick to their prescription regimens, according to a new study led by researchers at the University of Pittsburgh School of Pharmacy. The findings, reported today in Health Affairs, suggest also that greater adherence to medications can lead to a reduction in emergency room visits and hospital admissions, thereby [...]

Gene that regulates health of cell’s powerhouse could be target for developing new diabetes drugs

A team led by researchers from the Perelman School of Medicine at the University of Pennsylvania found that a susceptibility gene for type 1 diabetes regulates self-destruction of the cell’s energy factory. They report their findings this week in Cell. The pathway central to this gene could be targeted for prevention and control of type-1 [...]