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Scientists develop active substance for fatal muscle wasting in male children

Duchenne muscular dystrophy is a congenital disease which causes muscle degeneration and eventual death in teenagers. Recently, researchers from Bern developed an active substance, which they together with an international team tested successfully. Duchenne muscular dystrophy (DMD) is a relatively rare congenital disease which only affects boys and which leads to irreversible muscle wasting. Around [...]

Scientists identify new disease treatment path

Scientists at the University of Portsmouth have discovered a previously unknown phenomenon that means diseased muscle cells literally eat themselves to death. The researchers say this previously unrecognised mechanism could have far reaching effects for the understanding and treatment of diseases including cancers and inflammatory diseases, as well as Duchenne muscular dystrophy. The discovery was [...]

In Duchenne muscular dystrophy stem cells found to be faulty

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have found that the fault may lie at least partly in the stem cells that surround the muscle fibers. They’ve found that during the [...]

iPS cells used to correct genetic mutations that cause muscular dystrophy

Researchers at the Center for iPS Cell Research and Application (CiRA), Kyoto University, show that induced pluripotent stem (iPS) cells can be used to correct genetic mutations that cause Duchenne muscular dystrophy (DMD). The research, published in Stem Cell Reports, demonstrates how engineered nucleases, such as TALEN and CRISPR, can be used to edit the [...]

Innovative gene therapy treatment demonstrated in canine model of DMD

Duchenne muscular dystrophy is the most common neuromuscular disease of children (affecting 1 boy in 3500-5000 births). It is caused by a genetic defect in the DMD gene residing on the X chromosome, which results in the absence of the dystrophin protein essential to the proper functioning of muscles. The treatment being developed by researchers [...]