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One Specific MicroRNA Appears To Promote Tumor Growth And Cancer Spread

Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs [...]

Researchers Find Possible Molecular Key To Regulation Of Ovarian Cancer Stem Cells

Researchers at Moffitt Cancer Center have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. This knowledge, said the researchers, could pave the way for a therapeutic target for ovarian cancer. The study appears in a recent issue of the The Journal of Biological Chemistry. According [...]

Researchers Identify PHF20, A Regulator Of Gene P53, Critical For Normal Cell Growth And Tumor Suppression

Researchers at Moffitt Cancer Center and colleagues have identified PHF20, a novel transcriptional factor, and clarified its role in maintaining the stability and transcription of p53, a gene that allows for both normal cell growth and tumor suppression. PHF20, the researchers found, plays a previously unknown and unique role in regulating p53. When p53 is [...]