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Improved understanding of an understudied food allergy disorder, eosinophilic gastritis

Investigators at Cincinnati Children’s Hospital Medical Center have published the first study to extensively characterize eosinophilic gastritis (EG). The study, published in The Journal of Allergy and Clinical Immunology, found that EG is a systemic disorder that has high levels of eosinophils in the blood and gastrointestinal tract, involves a series of allergy-associated-immune mechanisms and [...]

In food allergic disease eosinophilic esophagitis, environment plays bigger role than genetics

Researchers have found that environment has a much stronger role than genetics in eosinophilic esophagitis (EoE), a severe, often painful food allergy that renders children unable to eat a wide variety of foods. Eosinophils are normal cellular components of the blood, but when the body produces too many eosinophils they can cause a variety of [...]

Treating eosinophilic esophagitis with high-dose fluticasone

Results from a clinical trial show that high doses of the corticosteroid fluticasone propionate safely and effectively induce remission in many people with eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus characterized by high levels of white blood cells called eosinophils. However, some trial participants did not respond to fluticasone even after six [...]

Improved genetic understanding of eosinophilic esophagitis

Scientists funded by the National Institutes of Health (NIH) have identified genetic markers associated with eosinophilic esophagitis (EoE), an inflammatory disease characterized by high levels of immune cells called eosinophils in the esophagus. Their findings suggest that several genes are involved in the development of EoE, which can cause difficulty eating and often is associated [...]

Cause of mysterious food allergy determined, new treatment strategy suggested

New research in Nature Genetics identifies a novel genetic and molecular pathway in the esophagus that causes eosinophillic esophagitis (EoE), opening up potential new therapeutic strategies for an enigmatic and hard-to-treat food allergy. EoE is a chronic inflammatory disorder of the esophagus. The condition is triggered by allergic hypersensitivity to certain foods and an over-accumulation [...]