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Blood-cerebrospinal fluid barrier function impaired by acrylamide

The blood-brain barrier prevents xenobiotics from entering the central nervous system. Growing evidence indicates that neurotoxins, such as tributyltin, manganese and nanoparticles, may disrupt the function of the blood-brain and blood-cerebrospinal fluid (CSF) barriers. Previous studies show that chronic acrylamide exposure leads to central and peripheral neuropathy. However, very few studies have focused on the [...]

Cholecystokinin octapeptide antagonizes apoptosis in retinal pigment epithelial cells

Oxidative stress may cause retinal pigment epithelial (RPE) cell apoptosis. Nitric oxide and superoxide react to produce peroxynitrite, which, along with its derivatives, are strong oxidants. Cholecystokinin octapeptide-8 (CCK-8) can protect cholinergic neurons against basal forebrain lesion caused by brain injury. The research team at Hebei Province People’s Hospital, China led by Dr. Yuan Liu [...]