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PEGASUS-TIMI 54 study data reinforce the need for long-term secondary prevention of cardiovascular events

AstraZeneca has announced details of a sub-analysis of the PEGASUS-TIMI 54 study, assessing the effect of Brilique™ (ticagrelor) in reducing atherothrombotic events in post-heart attack patients, based on the time from withdrawal of their previous P2Y12 inhibitor antiplatelet therapy. Current European guidelines recommend that dual antiplatelet therapy is stopped 12 months after a heart attack. [...]

FDA approves expanded indication for Brilinta to include long-term use in patients with a history of heart attack

AstraZeneca has announced that the US Food and Drug Administration (FDA) has approved BRILINTA® (ticagrelor) tablets at a new 60mg dose to be used in patients with a history of heart attack beyond the first year. With this expanded indication, BRILINTA is now approved to reduce the rate of cardiovascular death, myocardial infarction (MI also [...]

Cyclosporine does not improve outcomes after PCI

The immunosuppressant drug cyclosporine did not improve clinical outcomes compared to placebo in patients receiving percutaneous coronary intervention (PCI) for the more severe form of heart attack known as ST-segment elevation myocardial infarction (STEMI). Results of the CIRCUS trial, presented in a Hot Line session at ESC Congress 2015, and published simultaneously in the New [...]

Study of ‘fountain of youth’ protein points to possible human health benefit

Patients with higher blood levels of growth factor have lower risk of cardiovascular problems Individuals previously diagnosed with heart disease may be less likely to experience heart failure, heart attacks, or stroke, or to die from these events, if they have higher blood levels of two very closely related proteins, according to a new study [...]

Quitting smoking after heart attack reduces chest pain, improves quality of life

Smokers who quit after having a heart attack have similar levels of chest pain and mental health as non-smokers, according to research in the American Heart Association journal Circulation: Cardiovascular Quality and Outcomes. Researchers assessed 4,003 adults in two U.S. multi-center heart attack patient registries for smoking, chest pain and health-related quality of life measures, [...]