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Digital ‘Rosetta Stone’ decrypts how mutations rewire cancer cells

Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments. Since the human genome was decoded more than a decade ago, cancer genomics studies have dominated life science worldwide and have been extremely successful at identifying mutations in individual patients [...]

Bacteria that prevents type 1 diabetes

Our bodies have ten times the amount of microbes than human cells. This set of bacteria is called microbiota. In some instances, bacteria known as pathogens can cause infectious diseases. However, these micro-organisms can also protect us from certain diseases. Researchers from Inserm, Paris Descartes University and the CNRS (French National Centre for Scientific Research), [...]

Antibody’s unusual abilities might inspire vaccine strategies

The antibody shows promise both for stopping E. coli from adhering to cells and for dislodging it E. coli bacteria showing the appendages used to adhere to other cells. For example, certain forms of E. coli can attached to human cells in the urinary tract to cause infection. Credit: Sokurenko lab/University of Washington __SOURCEFROM__ The [...]

Human stem cells repair damage caused by radiation therapy for brain cancer in rats

For patients with brain cancer, radiation is a powerful and potentially life-saving treatment, but it can also cause considerable and even permanent injury to the brain. Now, through preclinical experiments conducted in rats, Memorial Sloan Kettering Cancer Center researchers have developed a method to turn human stem cells into cells that are instructed to repair [...]

New method identifies genome-wide off-target cleavage sites of CRISPR-Cas nucleases

Massachusetts General Hospital (MGH) investigators have developed a method of detecting, across the entire genome of human cells, unwanted DNA breaks induced by use of the popular gene-editing tools called CRISPR-Cas RNA-guided nucleases (RGNs). Members of the same team that first described these off-target effects in human cells describe their new platform, called Genome-wide Unbiased [...]