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Spheroid stem cell production sows hope for IPF treatment

In a small pilot study, researchers from North Carolina State University have demonstrated a rapid, simple way to generate large numbers of lung stem cells for use in disease treatment. This method of harvesting and growing a patient’s own lung stem cells shows promise in mice for treating idiopathic pulmonary fibrosis (IPF), and could one [...]

Increased protein turnover contributes to the development of pulmonary fibrosis

Scientists of the Comprehensive Pneumology Center (CPC) at the Helmholtz Zentrum München have identified a new mechanism which contributes to the development of idiopathic pulmonary fibrosis (IPF). They showed that the pathological changes of lung tissue are accompanied by an increase in protein turnover by the central protein degradation machinery of the cell – the [...]

CNIO researchers show that telomeres are linked to the origins of idiopathic pulmonary fibrosis

These results suggest that idiopathic pulmonary fibrosis may be treated by therapies based on the activation of the enzyme telomerase Idiopathic pulmonary fibrosis (IPF) causes a gradual loss of respiratory capacity and can be lethal within a few years. The cause is unknown, although it can be attributed to a combination of genetics and the [...]

Study provides insights on chronic lung disease

A new study shows that shorter telomeres–which are the protective caps at the end of a cell’s chromosomes–are linked with worse survival in a progressive respiratory disease called idiopathic pulmonary fibrosis (IPF). In patients with IPF, excessive scar tissue forms in the lungs. The average telomere length of IPF patients was significantly shorter than that [...]

New approach for treating idiopathic pulmonary fibrosis

Researchers at Helmholtz Zentrum München, in collaboration with an international team, have identified a potential novel drug target for idiopathic pulmonary fibrosis, a dangerous chronic lung disease. They elucidated a new mechanism of fibrosis formation that plays an important role in the pathogenesis of the disease. These findings have now been published in the leading [...]