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Which patients will respond to melanoma immunotherapy?

Patients with metastatic melanoma who have benefited from a new type of cancer immunotherapy don’t appear to share the same tumor-produced antigens, according to a new report by Eliezer Van Allen and colleagues. If the molecular targets for the immunotherapy differ from patient to patient, as this study suggests, it may be difficult to predict [...]

Magnetic nanoparticles could be key to effective immunotherapy

In recent years, researchers have hotly pursued immunotherapy, a promising form of treatment that relies on harnessing and training the body’s own immune system to better fight cancer and infection. Now, results of a study led by Johns Hopkins investigators suggests that a device composed of a magnetic column paired with custom-made magnetic nanoparticles may [...]

Immunotherapy drug improves survival for common form of lung cancer

In a head-to-head clinical trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous-non-small cell lung cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy. Squamous non-small cell lung cancer accounts for 25 to 30 percent of all lung malignancies. Results of the trial, reported [...]

UTMB scientists use immunotherapy to reduce memory problems with Alzheimer’s disease in mice

A new study from the University of Texas Medical Branch at Galveston has revealed that a single dose of an immunotherapy reverses memory problems in an animal model of Alzheimer’s disease. The article appears in the March 25 issue of the Journal of Neuroscience. Researchers have been working for decades to map out how Alzheimer’s [...]

Gene alterations in melanoma may predict immunotherapy outcomes

Among melanoma patients who were treated with immunotherapies, those whose tumors had mutations in the gene NRAS had better response and treatment outcomes than those whose tumors did not have NRAS mutations. The study is published in Cancer Immunology Research, a journal of the American Association for Cancer Research. Although immunotherapies have become a main [...]