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Approval of Praluent (alirocumab) for the treatment of hypercholesterolemia in the European Union

Sanofi and Regeneron Pharmaceuticals, Inc. announced today that the European Commission (EC) has granted marketing authorization for Praluent® (alirocumab) for the treatment of bad cholesterol, known as low-density lipoprotein (LDL) cholesterol, in certain adult patients with hypercholesterolemia. Praluent is the only EC-approved PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that is available in two starting [...]

Gene therapy fully restores vision in mouse model of Leber congenital amaurosis

Mice lacking the protein retGC1, which is deficient in humans suffering Leber congenital amaurosis-1 (LCA1), a disorder that causes severe visual impairment beginning in infancy, received gene therapy to replace retGC1 and showed fully restored visual function that persisted for at least 6 months. The success of this approach strongly support clinical testing of a [...]

Optimizing effectiveness of CAR T cell therapy in lymphoma highlighted in special nordic issue

Chimeric antigen receptor (CAR) T cells, which can specifically recognize and target tumor cells, have resulted in complete responses in patients with leukemia, and although equally promising for treating lymphoma, obstacles remain and individual patient responses CAR T cell therapy have varied. The main barriers to overcome in developing the next generation of CAR T [...]

Is hospice use alone a good indicator of quality of end-of-life care?

Hospice use is commonly accepted as an indicator of quality of end-of-life care, however, when researchers in the U.S. studied variations in patterns of hospice use between states, they found troubling trends. They discuss the variations in the timing and duration of hospice enrollment and their implications in an article published in Journal of Palliative [...]

Research from Harvard and Johns Hopkins shows surge in journal articles on yoga therapy

During the last 10 years, the number of articles in peer-reviewed journals worldwide about clinical trials of yoga therapy to alleviate disease-related symptoms increased 3-fold. This large-scale analysis of published research studies spanning 46 years, 29 countries, and more than 28,000 study participants is published in The Journal of Alternative and Complementary Medicine, a peer-reviewed [...]