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Combination weight loss drugs hard to tolerate, but efficacious

Soon-to-be-available combination medication may be a viable option for obese Australians seeking to lose weight and maintain the loss, but only if they can manage its adverse effects, according to research published in the Medical Journal of Australia. A combination of phentermine (a sympathomimetic agent that suppresses appetite) and topiramate (which is used to treat [...]

Topiramate helps curb cocaine addictions

The drug topiramate, typically used to treat epilepsy and more recently weight loss, may also help people addicted to both cocaine and alcohol use less cocaine, particularly heavy users, researchers in the department of Psychiatry at Penn Medicine report in a new study published in Drug and Alcohol Dependence. Results from the double-blind, placebo-controlled trial [...]

A Promising New Pharmacotherapy For Treating Cocaine Dependence

Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence on one’s lifestyle, and the tendency of cocaine to attract people who make poor life choices and then exacerbate impulsive behavior all make cocaine a vexing clinical [...]