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Nanoparticle ‘wrapper’ delivers chemical that stops fatty buildup in rodent arteries

Experimental therapy restores normal fat metabolism in animals with atherosclerosis In what may be a major leap forward in the quest for new treatments of the most common form of cardiovascular disease, scientists at Johns Hopkins report they have found a way to halt and reverse the progression of atherosclerosis in rodents by loading microscopic [...]

Scientists identify amino acid that stops seizures in mice

Finding suggests novel mechanism for treating epilepsy An amino acid whose role in the body has been all but a mystery appears to act as a potent seizure inhibitor in mice, according to a study by researchers at Johns Hopkins. In a series of experiments, the amino acid D-leucine, found in many foods and certain [...]

New imaging technique could make brain tumor removal safer, more effective, study suggests

Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact — and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an [...]

Vulnerabilities in genome’s ‘dimmer switches’ should shed light on many complex diseases

Up to one-fifth of human DNA act as dimmer switches for nearby genes, but scientists have long been unable to identify precisely which mutations in these genetic control regions really matter in causing common diseases. Now, a decade of work at Johns Hopkins has yielded a computer formula that predicts with far more accuracy than [...]

Immunotherapy drug improves survival for common form of lung cancer

In a head-to-head clinical trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous-non-small cell lung cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy. Squamous non-small cell lung cancer accounts for 25 to 30 percent of all lung malignancies. Results of the trial, reported [...]