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Optimizing effectiveness of CAR T cell therapy in lymphoma highlighted in special nordic issue

Chimeric antigen receptor (CAR) T cells, which can specifically recognize and target tumor cells, have resulted in complete responses in patients with leukemia, and although equally promising for treating lymphoma, obstacles remain and individual patient responses CAR T cell therapy have varied. The main barriers to overcome in developing the next generation of CAR T [...]

Novel drug shuts down master protein key to lymphoma

Researchers have discovered how an experimental drug is capable of completely eradicating human lymphoma in mice after just five doses. The study, led by researchers at Weill Cornell Medical College, sets the stage for testing the drug in clinical trials of diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, itself the [...]

Link Discovered Between Intestinal Bacteria And White Blood Cell Cancer

Researchers from UCLA’s Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma, a cancer of the white blood cells. Published online ahead of press in the journal Cancer Research, the study was led by Robert Schiestl, member of the Jonsson Cancer Center and [...]

First Large-Scale Comparison Shows Human And Canine Lymphomas Share Molecular Similarities

Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it’s the most common lymphoma subtype while in dogs, it’s one of the most common cancers in veterinary oncology. A team of scientists from the University of North Carolina School of [...]

Scheduled Imaging Studies Provide Little Help Detecting Relapse Of Aggressive Lymphoma

Imaging scans following treatment for diffuse large B-cell lymphoma do little to help detect a relapse, a Mayo Clinic study has found. The overwhelming majority of patients with this aggressive lymphoma already have symptoms, an abnormal physical exam or an abnormal blood test at the time of relapse, the researchers say. The findings will be [...]