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Is hospice use alone a good indicator of quality of end-of-life care?

Hospice use is commonly accepted as an indicator of quality of end-of-life care, however, when researchers in the U.S. studied variations in patterns of hospice use between states, they found troubling trends. They discuss the variations in the timing and duration of hospice enrollment and their implications in an article published in Journal of Palliative [...]

Genetic markers linking risk for type 2 diabetes and Alzheimer’s identified

Certain patients with type 2 diabetes (T2D) may have specific genetic risk factors that put them at higher risk for developing Alzheimer’s disease (AD), according to a study conducted at the Icahn School of Medicine at Mount Sinai and published recently in Molecular Aspects of Medicine. Under the leadership of Giulio Maria Pasinetti, MD, PhD, [...]

Scientists develop more accurate whole genome variant discovery and interpretation

A new strategy for uncovering difficult-to-detect, complex forms of genomic variation associated with human disease Scientists from the Icahn School of Medicine at Mount Sinai have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping. The methodology enabled researchers to detect complex forms of genomic variation, critically [...]

Discovery may lead to targeted melanoma therapies

Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a study led by researchers at Icahn School of Medicine at Mount Sinai and published online in the journal Molecular Cell. The research team found that the protein, called H2A.Z.2, promotes the abnormal [...]

Mount Sinai scientists develop new technique for analyzing the epigenetics of bacteria

Scientists from the Icahn School of Medicine at Mount Sinai have developed a new technique to more precisely analyze bacterial populations, to reveal epigenetic mechanisms that can drive virulence. The new methods hold the promise of a potent new tool to offset the growing challenge of antibiotic resistance by bacterial pathogens. The research was published [...]