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PEGASUS-TIMI 54 study data reinforce the need for long-term secondary prevention of cardiovascular events

AstraZeneca has announced details of a sub-analysis of the PEGASUS-TIMI 54 study, assessing the effect of Brilique™ (ticagrelor) in reducing atherothrombotic events in post-heart attack patients, based on the time from withdrawal of their previous P2Y12 inhibitor antiplatelet therapy. Current European guidelines recommend that dual antiplatelet therapy is stopped 12 months after a heart attack. [...]

EXAMINATION trial shows superiority of second generation drug-eluting stent at five years

The EXAMINATION trial has demonstrated the superiority of a second generation drug-eluting stent over a bare-metal stent at five years in research presented at ESC Congress. “This is the first time since primary percutaneous coronary intervention (PCI) demonstrated superiority over thrombolysis that a device (stent) has shown clinical benefit beyond restenosis prevention in a randomised [...]

Peri-infarct pacing does not improve outcomes in patients with large myocardial infarction

In patients with a large myocardical infarction (MI), pacing, with the left ventricular (LV) lead placed in the area of the lesion (peri-infarct) did not prevent further enlargement of the heart (remodeling), nor did it improve functional or clinical outcomes after 18 months, according to results of the Pacing Remodeling Prevention Therapy trial (PRomPT) trial. [...]

Cyclosporine does not improve outcomes after PCI

The immunosuppressant drug cyclosporine did not improve clinical outcomes compared to placebo in patients receiving percutaneous coronary intervention (PCI) for the more severe form of heart attack known as ST-segment elevation myocardial infarction (STEMI). Results of the CIRCUS trial, presented in a Hot Line session at ESC Congress 2015, and published simultaneously in the New [...]

Less extensive damage to heart muscle/therapeutic hypothermia following acute myocardial infarction

After an acute myocardial infarction, patients treated with rapid lowering of body temperature by combined cold saline infusion and endovascular cooling had less heart muscle damage and reduced incidence of heart failure. Therapeutic hypothermia was especially protective against heart muscle damage in patients with a large area of myocardium at risk according to an analysis [...]