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Removing a protein enhances defense against bacteria staphylococcus aureus in CGD mice

Deletion of a protein in white blood cells improves their ability to fight the bacteria staphylococcus aureus and possibly other infections in mice with chronic granulomatous disease (CGD), according to a National Institutes of Health study. CGD, a genetic disorder also found in people, is marked by recurrent, life-threatening infections. The study’s findings appear online [...]

Therapeutic Targets Found To Alter Inflammation, Type 2 Diabetes

New research from Boston University School of Medicine (BUSM) reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms. The study, published in the Proceedings of the National Academies of Sciences, indicates the importance of continuing to explore B cells as a therapeutic target to treat these diseases. Barbara Nikolajczyk, [...]

Identification Of Molecular Master Switch For Pancreatic Cancer, Potential Predictor Of Treatment Outcome

A recently described master regulator protein may explain the development of aberrant cell growth in the pancreas spurred by inflammation A team from the Perelman School of Medicine at the University of Pennsylvania profiled gene expression of mouse pancreatic ductal and duct-like cells from different states – embryonic development, acute pancreatitis and K-ras mutation-driven carcinogenesis [...]

Research Shows Exercise As Key In Reducing Body Fat While Preserving Muscle

Exercise and healthy eating reduce body fat and preserve muscle in adults better than diet alone, according to a study funded and conducted by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The study was recently published online in Obesity and will be in a future [...]

Biochemists Open Path To Molecular ‘Chaperone’ Therapy For Metabolic Disease

University of Massachusetts Amherst researchers, experts in revealing molecular structure by X-ray crystallography, have identified two new small “chaperone” molecules that may be useful in treating the inherited metabolic disorder known as Schindler/Kanzaki disease. This offers hope for developing the first ever drug treatment for this very rare disease. Findings are reported in the current [...]