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Viral protein in their sights

Advanced imaging reveals key structure of Ebola and other RNA viruses This is the structure of the L-protein of vesicular stomatitis virus from electron cryomicroscopy. Credit: Simon Jenni __SOURCEFROM__ The research was supported by National Institutes of Health grants GM62580, AI059371 and AI057159 (New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases). [...]

Targeting nerve endings to curb allergic asthma

New treatment approach could break a vicious cycle of neuro-immune signaling Fig 1 F/G: Activation of nociceptors, done for study purposes with a compound called capsaicin, promotes the infiltration of immune cells into the lung (right) as compared with control (left). Credit: Courtesy of Boston Children’s Hospital __SOURCEFROM__ Supporters of the study include the Hood [...]

NIH-funded researchers identify new genetic immune disorder

Researchers funded by the National Institutes of Health (NIH) have identified a new immune disorder–DOCK2 deficiency–named after the mutated gene responsible for the disease. An international team of collaborators studied five children, four boys and one girl, from different ethnic backgrounds who had experienced debilitating infections early in life. The children were diagnosed with combined [...]

Genetically predicted higher BP linked to antihypertensive use and lower Alzheimer’s risk

Genetic variants that predict higher systolic blood pressure (SBP) are associated with a higher probability of taking antihypertensive medication and with decreased risk of Alzheimer disease (AD), according to a study published this week in PLOS Medicine. The study, conducted by Robert Scott of the MRC Epidemiology Unit, University of Cambridge, UK, Soren Ostergaard, (Aarhus [...]

Patients struggle to stick to their diet when they choose a plan they like; myalgic encephalomyelitits/chronic fatigue syndrome

1. Patients struggle to stick to their diet when they choose a plan they like Researchers say it’s counterintuitive, but letting patients choose a diet plan based on personal preference may not help them lose weight. The results of a randomized trial are published in Annals of Internal Medicine. Regardless of the approach, greater adherence [...]