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Corrected protein structure reveals drug targets for cancer, neurodegenerative diseases

Study revises previously published structure of Protein Kinase C enzyme, proposes new strategies to turn the enzyme ‘on’ to treat cancer or ‘off’ to treat neurodegenerative diseases Study co-authors Corina Antal (left) and Julia Callender (right) are holding the pieces of a new PKC model. Credit: UC San Diego Health

Brain disease scenarios revised by step-by-step imaging of toxic aggregation

Diseases like Alzheimer’s are caused when proteins aggregate and clump together. In a world first, EPFL scientists have successfully distinguished between the disease-causing aggregation forms of proteins. The finding can help change pharmaceutical treatment of neurodegenerative diseases. Because of our increasing lifespan, diseases like Parkinson’s, Huntington’s and Alzheimer’s are on the rise. They are caused [...]

Chemists find efficient, scalable way to synthesize potential brain-protecting compound

Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting properties. Finding a good way to synthesize jiadifenolide has been a goal of chemists around the world since the compound was discovered in 2009. Preliminary studies have hinted that it [...]

Scientists identify new drug target to treat ALS

Revelations about a key cellular pathway have important implications for neurodegenerative diseases like ALS and frontotemporal dementia Blue is the nucleus, cyan is hUPF1, green is TDP43, red is the cell body in this image. Credit: Sami Barmada __SOURCEFROM__ Scientists from the University of California San Francisco, Wright State University, Brandeis University, and Weill Cornell [...]

No evidence that low-frequency magnetic fields accelerate development of Alzheimer’s, ALS

Research study by the Mainz University Medical Center investigates the influence of low-frequency magnetic fields on neurodegenerative diseases In the case of animal model Alzheimer’s disease, age-related deposits of amyloid-beta protein develop in the brain. This protein can be labeled and thus made visible under a fluorescence microscope. Credit: photo/©: Albrecht Clement __SOURCEFROM__ Johannes Gutenberg [...]