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Cholesterol metabolism in immune cells linked to HIV progression, may lead to new therapy

Enhanced cholesterol metabolism in certain immune cells may help some people infected with HIV naturally control disease progression, according to new research from the University of Pittsburgh Graduate School of Public Health. The findings – funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH) and presented [...]

NIH-funded researchers identify new genetic immune disorder

Researchers funded by the National Institutes of Health (NIH) have identified a new immune disorder–DOCK2 deficiency–named after the mutated gene responsible for the disease. An international team of collaborators studied five children, four boys and one girl, from different ethnic backgrounds who had experienced debilitating infections early in life. The children were diagnosed with combined [...]

West African Ebola virus strain less virulent than prototype 1976 strain

Comparison shows delayed disease progression The Makona strain of Ebola virus (EBOV) circulating in West Africa for the past year takes roughly two days longer to cause terminal disease in an animal model compared to the original 1976 Mayinga strain isolated in Central Africa, according to a new National Institutes of Health (NIH) report. The [...]

Microchip captures clusters of circulating tumor cells — NIH study

Researchers have developed a microfluidic chip that can capture rare clusters of circulating tumor cells, which could yield important new insights into how cancer spreads. The work was funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health. A fluorescently labelled cancer cell cluster balances on the [...]

New insight into inflammatory bowel disease may lead to better treatments

Inflammatory bowel disease (IBD) afflicts 1.6 million people in the United States, causing abdominal pain, diarrhea, constipation, rectal bleeding and other potentially debilitating symptoms. Marked by yellow tags, the tiny particles released by this bacterium may help initiate inflammatory bowel disease, according to new research from Washington University School of Medicine in St. Louis. Credit: [...]