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The final word on STAP – Researchers fail to replicate STAP study; computational analysis reveals genomic inconsistency

Tremendous controversy erupted in early 2014 when two papers published in Nature described how a technique called “stimulus-triggered acquisition of pluripotency,” or STAP, could quickly and efficiently turn ordinary cells into pluripotent stem cells, that is, stem cells capable of developing into all the tissues in the body. The simplicity of the approach–subjecting the cells [...]

New biotechnology for high efficiency purification of live human cells

One of the reasons pluripotent stem cells are so popular in medical research is that they can be differentiated into any cell type. However, typical differentiation protocols lead to a heterogeneous population from which the desired type must be purified. Normally, antibodies that react to surface receptors unique to the desired cell are used for [...]

A new tool for understanding ALS: Patients’ brain cells

Researchers create a free public library of versatile stem cells from ALS patients Fast Facts: More than 30,000 people in the U.S. are diagnosed with Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS). Johns Hopkins researchers have transformed skin cells donated by ALS patients into brain cells affected by the progressive, fatal disease. The resulting [...]

Neurons controlling appetite made from skin cells

Cells provide individualized model for studying obesity and testing treatments Columbia researchers have developed a method to generate hypothalamic-like neurons from human pluripotent stem cells. The hypothalamic cells, which are ordinarily inaccessible for direct investigation, will help the researchers study obesity. Credit: Laboratory of Rudolph Leibe__SOURCEFROM__ The paper is titled, “Differentiation of hypothalamic-like neurons from [...]

New reporter system to study bone-related regenerative medicine generated by UMN labs

A new reporter system used to study the bone regeneration potential of human embryonic stem cells has been generated in research led by the University of Minnesota. The new reporter system is the first of its kind for human pluripotent stem cells and is important for identifying certain agents and pathways that mediate early stages [...]