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UI Health validates cure for sickle cell in adults

Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings. The transplants were the first to be performed outside of the National Institutes of Health campus in Maryland, where the procedure was developed. [...]

Research shows NHS could save blood and money

Changing clinical thresholds for the single leading reason for blood transfusions could safely produce significant savings for the NHS, according to NHS Blood and Transplant (NHSBT) research published in The Lancet. The results come in the first reported multicentre randomised trial comparing red blood cell transfusion strategies for Acute Upper Gastrointestinal Bleeding (AUGIB). The TRIGGER [...]

Scientists identify progenitor cells for blood and immune system

UCSF researchers aim for better balance of cell populations to combat aging and cancer University of California San Francisco scientists have identified characteristics of a family of daughter cells, called MPPs, which are the first to arise from stem cells within bone marrow that generate the entire blood system. The researchers said the discovery raises [...]

Cozy niches: certain host cell environments make malaria parasites resistant to drugs

Of the two species of Plasmodium parasites commonly infecting humans, P. vivax grows exclusively in immature red blood cells called reticulocytes. P. falciparum can infect reticulocytes, but it grows primarily in mature red blood cells (called erythrocytes) which make up 99% of red cells in circulation. A study published on June 4th in PLOS Pathogens [...]

Repurposed anti-cholesterol drug could improve treatment-resistant anemias

Each year, between 25 and 35 children in the United States and Canada are diagnosed with an inherited bone marrow failure syndrome called Diamond Blackfan anemia (DBA), according to the US Centers for Disease Control and Prevention. Although rare, this syndrome causes a deficiency in producing red blood cells that is devastating for patients and [...]