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Contrary to previous studies, diabetes affects diaphragm, smooth muscle cells differently

Discovery could lead to better research of respiratory failure in individuals with diabetes Previous studies have shown that diabetes adversely affects breathing and respiratory function. However, in the past, researchers have not differentiated diaphragm muscle cells and the muscle cells of limb skeletal muscle in their studies. Now, researchers from the University of Missouri have [...]

Fat mice bred to have more muscle give insight, new targets for battling obesity’s cardiovascular risk

Even without losing fat, more muscle appears to go a long way in fighting off the bad cardiovascular effects of obesity. That emerging evidence has scientists looking hard for new targets to uncouple the unhealthy relationship between fat and cardiovascular disease. “If you look at the exercise literature, we understand very well that if you [...]

Skeletal muscle atrophy in congestive heart failure

MDC and Charité researchers elucidate mechanism It is a paradox: Patients with advanced congestive heart failure lose skeletal muscle mass, but their heart muscles become enlarged to provide the body with an adequate supply of blood and thus with oxygen. It has long been known that the protein angiotensin II plays a villainous role in [...]

Autophagy defect causes loss of muscle in aging

Unbalanced p62/SQSTM1 and LC3 expression in sarcopenic muscle of mice Sarcopenia is the aging-related loss of skeletal muscle mass and strength. Preventing sarcopenia is important for maintaining a high quality of life (QOL) in the aged population. However, the molecular mechanism of sarcopenia has not yet been unraveled and is still a matter of debate. [...]

Into thin air and back

New deer mouse study examines muscle performance and high altitude adaptation Life has adapted to all sorts of extreme environments on Earth, among them, animals like the deer mouse, shimmying and shivering about, and having to squeeze enough energy from the cold, thin air to fuel their bodies and survive. Now, in a new publication [...]