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Study finds weight loss in obese adults can reduce severity of asthma

Behavioral weight loss program associated with improvements in airway hyperresponsiveness and quality of life A Canadian study published in the June issue of the journal CHEST found weight loss reduced asthma severity as measured by airway hyperresponsiveness (AHR) in obese adults. The incidence of asthma is 1.47 times higher in obese people than nonobese people, [...]

Obesity and weight loss change splicing pattern of obesity and type 2 diabetes genes

Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. However, weight loss, induced by either obesity [...]

Ease of weight loss influenced by individual biology

NIH study finds varied responses to calorie restriction in obese adults For the first time in a lab, researchers at the National Institutes of Health found evidence supporting the commonly held belief that people with certain physiologies lose less weight than others when limiting calories. Study results published in Diabetes. Researchers at the Phoenix Epidemiology [...]

More weight-loss strategies needed for people with neurological disabilities

A review of nutrition and weight-loss interventions for people with impaired mobility found strategies are sorely lacking for people with neurological disabilities, according to a team of researchers from Case Western Reserve University and Cleveland Clinic. Interventions are overwhelmingly geared toward muscular disorders, leaving a gap in approaches that could help people with neurological disabilities [...]

Liraglutide may help overweight and obese adults lose weight safely and effectively

Obesity guidelines recommend an initial weight loss goal of 5 to 10% of start weight to improve health. A recent study found that patients who received liraglutide 3.0 mg, combined with fewer calories and more physical activity, were more than twice as likely to achieve at least that level of weight loss, compared to patients [...]