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Tau-associated MAPT gene increases risk for Alzheimer’s disease

Finding could improve dementia diagnosis and treatment

Alzheimer's Plaques and Tangles
This is a microscopic image depicting plaques and tangles characteristic of Alzheimer’s disease.
Credit: Image courtesy of Tom Deerinck, NCMIR, UC San Diego.


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Co-authors include , Linda K. McEvoy, Dominic Holland, James B. Brewer, Chi-Hua Chen, Wesley K. Thompson, UCSD; Yunpeng Wang, UCSD and ; Aree Witoelar, Ingun Dina Ulstein, Srdjan Djurovic, , Norway; Manu Sharma, Thomas Gasser, University of Tubingen, Germany; Denise Harold, Julie Williams, Michael J. Owen, Michael C. O’Donovan, , Wales; Margaret A. Pericak-Vance, University of Miami; Richard Mayeux, ; Jonathan L. Haines, ; Lindsay A. Farrer, Schools of Medicine and Public Health; Peter Heutink, German Center for Neurodegenerative Diseases; Andrew B. Singleton, Lenore Launer, National Institute on Aging; Alexis Brice, Sorbonne University; Nicolas Wood, John Hardy, University College London; Maria Martinez, INSERM; Seung Hoi Choi, Anita DeStefano, ; M. Arfan Ikram, Cornelia van Juijn, Erasmus MC University Medical Center; Joshua C. Bis, Annette L. Fitzpatrick, University of Washington; Albert Smith, Icelandic Heart Association; Dag Aarsland, Karolinska Institute, Sweden; Tormod Fladby, Akershus University Hospital, Norway; Bradley T. Hyman, Massachusetts General Hospital; Jon Snaedal, University Hospital Reykjavik, Iceland; and Hreinn Stefanson, Kari Stefanson, University of Iceland.

Funding for this research came, in part, the National Institutes of Health (grants R01AG031224, K01AG029218, K02NS067427, T32 EB005970, UO1AG032984, U24-AG041689, and R01 MH100351), the Research Council of Norway, the South East Norway Health Authority, the Norwegian Health Association and the KG Jebsen Foundation.

University of California – San Diego