There are plenty of body parts that don’t grow back when you lose them. Nails are an exception, and a new study published in The Proceedings of the National Academy of Sciences (PNAS) reveals some of the reasons why.
Stem cells in a mouse nail
Credit: Image courtesy of the Krzysztof Kobielak lab
Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration. PNASYvonne Leung, 15114–15119, doi: 10.1073/pnas.1318848111
Additional co-authors include USC researchers Yi-Bu Chen, Seth Ruffins and Cheng-Ming Chuong.
Funding came from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) Grants R03-AR061028, R01-AR061552, AR42177, AR 047364 and AR060306. Eve Kandyba is a Fellow of the California Institute for Regenerative Medicine (CIRM) Research Training Program II in Stem Cell Biology.