Macrophages are best known for their Pac Man-like ability to gobble up cellular debris and pathogens in order to thwart infection. A new study in The Journal of Cell Biology describes how these immune cells also help resolve inflammation by inducing white blood cells called neutrophils to leave wounded tissue.
These time-lapse images show macrophages (green) contacting neutrophils (magenta) and chasing them away from a wound (arrowhead).
Credit: Tauzin et al., 2014
Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. Tauzin, S., et al. 2014. J. Cell Biol. doi:10.1083/jcb.201408090
Research reported in the press release was supported by the American Heart Association and National Institutes of Health.