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To resolve inflammation, macrophages chase neutrophils away from wounds

Macrophages are best known for their Pac Man-like ability to gobble up and pathogens in order to thwart infection. A new study in The Journal of Cell Biology describes how these immune cells also help resolve by inducing called to leave wounded tissue.

[Macrophages Chase Neutrophils]
These time-lapse images show macrophages (green) contacting neutrophils (magenta) and chasing them away from a wound (arrowhead).
Credit: Tauzin et al., 2014


Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. Tauzin, S., et al. 2014. J. Cell Biol. doi:10.1083/jcb.201408090

Research reported in the press release was supported by the American Heart Association and National Institutes of Health.

Rockefeller University Press