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Total Eradication Of Malaria Has Longlasting Benefits For Many Countries

Many nations battling face an economic dilemma: spend money indefinitely to control transmission or commit additional resources to eliminate transmission completely. A review of elimination conducted by researchers at the Johns Hopkins Research Institute and other institutions suggests stopping transmission completely has longlasting benefits for many countries and that once eliminated, the disease is unlikely to reemerge over time. Furthermore, total eradication of may not be necessary before countries that eliminate the disease within their own borders can rely on their health systems to control cases. The study is published in the February 22 edition of Science.

“Our research identified a number of changes that could explain the stability of malaria elimination. The key for us now is to determine whether elimination caused some of these changes, and to identify other countries where elimination could become a stable endpoint,” said the study’s senior author, David Smith, PhD, MS, professor in the Department of Epidemiology and the at the Johns Hopkins Bloomberg School of Public Health.

For the analysis, the researchers examined outcomes of the , with activities starting in the late 1940s. When the program was defunded in 1969, the majority of countries that had achieved elimination stayed that way, while most countries that did not eliminate the disease continue to battle malaria today. The study analyzed data from countries that eliminated malaria, describing nearly a quarter of a million imported – usually acquired during travel – compared with only about five thousand transmitted in-country. in elimination countries is rare today.

The researchers developed six hypotheses as to why malaria elimination remains stable over time. Among the reasons, researchers question whether economic development spurs a reduction in malaria transmission, independent of disease control measures, or if economic development is a byproduct of reduced illness from malaria. Other hypotheses consider benefits of mosquito control measures, effectiveness of outbreak management, and population travel patterns as reasons for keeping importation of new malaria infections low.

“If malaria elimination helps cause its own stability, then eradication may benefit from regional coordination, but it does not require a globally coordinated campaign. Malaria elimination can proceed like a ratchet, country-by-country and region-by-region, culminating in global eradication,” explained Smith.


”The Stability of Malaria Elimination” was written by C. Chiyaka, A.J. Tatem, J.M. Cohen, P.W. Gething, G. Johnston, R. Gosling, R. Laxminarayan, S.I. Hay, and D.L. Smith.
The researchers were funded by grants from the Bloomberg Family Foundation, the National Institute for Allergy and Infectious Diseases at NIH, the Bill & Melinda Gates Foundation, the U.S. Department of Homeland Security, the Fogarty International Center at NIH, and the Wellcome Trust.
Johns Hopkins University Bloomberg School of Public Health