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Tracking Malaria Parasites In The Liver

Plasmodium falciparum is the most deadly , causing more than 800,000 deaths per year. After the parasite enters the blood stream, it travels to the liver where it serially invades (hepatocytes), until it settles down to form a parasitophorous vacuole (PV). Once ensconced in its PV, the parasite undergoes a process known as liver stage (LS) during which it spawns tens of thousands of new parasites.

In this issue of the Journal of Clinical Investigation, and colleagues at the on a human liver-chimeric mouse that replicates P. falciparum LS development in humans. This is the first reliable model for the study of the P. falciparum LS stage and will be important for understanding human host/parasite interactions during the course of malaria infection.

“Complete Plasmodium falciparum liver stage development in liver-chimeric mice”
Stefan Kappe
Seattle Biomedical Research Institute, Seattle, WA, USA


Journal of Clinical Investigation Sept. 10, 2012