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Treating Parkinson’s disease by solving the mysteries of movement

Two secrets of one of the brain’s most enigmatic regions have finally been revealed. In a pair of new studies, scientists from the Gladstone Institutes have discovered a specific neural circuit that controls walking, and they found that input to this circuit is disrupted in Parkinson’s disease.

Neurons in the Brainstem Activated by Optogenetics
These are neurons in the brainstem involved in walking are lit up using optogenetics. [Roseberry et al., Cell]
Credit: Tom Roseberry, Gladstone Institutes