New research identifies promising therapeutic target for treating Alzheimer’s disease
This is a 3-D reconstruction of an immune cell (red) containing ?-amyloid (blue) within an intracellular degradation compartment (yellow). Deletion of the anti-inflammatory cytokine, Il10, activates innate immune cells to clear the brain of toxic ?-amyloid plaques.
Credit:Marie-Victoire Guillot-Sestier, Ph.D.
USC co-authors include Marie-Victoire Guillot-Sestier, Kevin R. Doty, David Gate, Javier Rodriguez, Jr., and Brian P. Leung. The study was supported in part by the National Institutes of Health (1F31NS083339-01A1, 5R00AG029726-04, 3R00AG029726-04S1, 1R01NS076794-01), American Federation of Aging Research/Ellis Medical Foundation and Zilkha Neurogenetic Institute.