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Using a fluorescent microscope and 3D diffusion modeling researchers can see how unfolded proteins move in the cell

When a large protein unfolds in transit through a , it slows down and can get stuck in traffic. Using a specialized microscope – a sort of cellular traffic camera – chemists now can watch the way the diffuses.

[looking at the dynamics of how the unfolded protein moved in the cell]
By looking at the dynamics of how the unfolded protein moved in the cell (A), the researchers mapped areas in the cell with different rates of diffusion (B and C).
Credit: Photo courtesy Hannah Gelman


Source

The supported this work.

The paper, “Coupled Protein Diffusion and Folding in the Cell ,”Published: December 01, 2014 DOI: 10.1371/journal.pone.0113040

University of Illinois at Urbana-Champaign