Viruses Prompt Oncogenic Transformation By Genetically Altering Infected Cells As Seen In Hepatitis B
In this issue of the Journal of Clinical Investigation, Xiaoje Xu and colleagues at the Beijing Institute of Biotechnology report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote growth and metastasis of liver cancer.
In normal liver cells, miR-148a represses the expression of the oncogenic protein HPIP, but the hepatitis B virus prevents expression of miR-148a, leading to increased levels of HPIP and subsequent oncogenic transformation.
This study demonstrates that a cancer-associated virus promotes carcinogenesis through direct manipulation of a microRNA.
TITLE: Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis