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Yeast are first cells known to cure themselves of prions

Yeast cells can sometimes reverse the and clumping associated with diseases such as Alzheimer’s, according to new research from the .

[Yeast Cells Can Clear Amyloid]
When colonies of baker’s yeast cells that contain clumped (colonies of on left) are stressed by high temperatures, some can convert the aggregated to the non-clumping form of the protein (red cells in the colonies the right).
Credit: Serio laboratory/ University of Arizona molecular and cellular biology


Source

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

DOI: http://dx.doi.org/10.7554/eLife.04288 Published December 9, 2014

University of Arizona