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Myofibroblast transdifferentiation is associated with changes in cellular and extracellular vesicle miRNA abundance

Myofibroblast transdifferentiation is associated with changes in cellular and extracellular vesicle miRNA abundance

Reworking development factor-beta 1 (TGF-β1), a pro-fibrotic tumour-derived issue promotes fibroblast differentiation within the tumour microenvironment and is believed to contribute to the event of pro-tumourigenic cancer-associated fibroblasts (CAFs) by selling myofibroblast differentiation. miRNA dysregulation has been demonstrated in myofibroblast transdifferentiation and CAF activation, nevertheless, their expression varies amongst cell varieties and with the tactic of […]