The rise in expression and activity of 11β-HSD1 in human mesenchymal progenitor cells induces adipogenesis through increased local cortisol synthesis

11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) performs an essential position in pre-receptor glucocorticoid metabolism. This enzyme is expressed in bone, will increase with age, and catalyzes the conversion of the inactive glucocorticoid cortisone into the energetic glucocorticoid cortisol and vice versa. Right here we hypothesized that the physiological exercise of 11β-HSD1 to provide cortisol in human mesenchymal […]