The large protein titin performs structure-preserving capabilities within the sarcomere and is vital for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play essential roles in regulating myocardial contraction, hypertrophy, and reworking. PKD phosphorylates myofilament proteins, however it’s not recognized whether or not the enormous protein titin can also be a PKD […]
![Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.](https://www.todaytopics.com/yt/uploads/2021/10/12.png)