The dysregulation of gene dosage as a consequence of duplication or haploinsufficiency is a significant reason for autosomal dominant illnesses equivalent to Alzheimer’s illness. Nevertheless, there’s at the moment no fast and environment friendly methodology for manipulating gene dosage in a human mannequin system equivalent to human induced pluripotent stem cells (iPSCs). Right here, we […]
![Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases](https://www.todaytopics.com/yt/uploads/2021/10/Efficient-manipulation-of-gene-dosage-in-human-iPSCs-using-CRISPRCas9-nickases.png)