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Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter.

Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter.

The dopamine transporter (DAT), which mediates the inactivation of launched dopamine by means of its reuptake, is the first molecular goal for the actions of psychostimulants. An rising variety of research assist an important position for phosphorylation of serines (Ser) within the distal amino (N) terminus of DAT in regulating its perform. Nonetheless, the molecular […]

Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases

Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases

The dysregulation of gene dosage as a consequence of duplication or haploinsufficiency is a significant reason for autosomal dominant illnesses equivalent to Alzheimer’s illness. Nevertheless, there’s at the moment no fast and environment friendly methodology for manipulating gene dosage in a human mannequin system equivalent to human induced pluripotent stem cells (iPSCs). Right here, we […]

Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans

Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans

On this examine, we studied the consequences of cortisol and cortisone on the age-related lower in locomotion within the nematode Caenorhabditis elegans and on the tolerance to warmth stress at 35 °C and to oxidative stress induced by the publicity to 0.1% H2O2. Adjustments in mRNA expression ranges of C. elegans genes associated to emphasize tolerance have been additionally […]