Compensatory Hippocampal Neurogenesis within the Absence of Cognitive Impairment Following Experimental Hippocampectomy in Grownup Rats
Postnatal Cytoarchitecture and Neurochemical Hippocampal Dysfunction in Down Syndrome
Conversely, Calr-ir cells and fibers have been noticed in any respect ages in DS, whereas NTD circumstances displayed primarily Calr-ir fibers. Hippocampal APP/Aβ-ir diffuse-like plaques have been seen in DS and NTD. In contrast, no Aβ1-42 or p-tau profiles have been noticed. These findings counsel that deficits in hippocampal neurogenesis and pyramidal cell maturation and elevated Calr immunoreactivity throughout early postnatal life contribute to cognitive impairment in DS.