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Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats.

Intramuscular administration of a VEGF zinc finger transcription…

Amyotrophic lateral sclerosis (ALS) is characterised by motor neuron loss resulting in paralysis and demise. Vascular endothelial progress issue (VEGF) has angiogenic, neurotrophic, and neuroprotective properties, and has preserved neuromuscular operate and guarded motor neurons…
Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.

Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via…

The large protein titin performs structure-preserving capabilities within the sarcomere and is vital for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play essential roles in regulating myocardial contraction, hypertrophy, and reworking.…