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Earliest molecular events leading to organ rejection identified in mice

Researchers at the University of Pittsburgh School of Medicine and the University of Toronto have uncovered the first molecular steps that lead to immune system activation and eventual rejection of a transplanted organ. The findings, published in Science Immunology, may be used someday to create better donor-recipient matches and develop new ways to prevent rejection [...]

Fungal toxins easily become airborne, creating potential indoor health risk

Toxins produced by three different species of fungus growing indoors on wallpaper may become aerosolized, and easily inhaled. The findings, which likely have implications for “sick building syndrome,” were published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. “We demonstrated that mycotoxins could be transferred from a moldy material to [...]

Guided self-help approach to graded exercise programme is safe and may reduce fatigue for patients with chronic fatigue syndrome

A self-help approach to a graded exercise programme, supervised by a specialist physiotherapist, is safe and may reduce fatigue for some people with chronic fatigue syndrome (CFS), according to a new trial of 200 people published in The Lancet. The intervention, undertaken over 12 weeks, had a smaller effect on reducing physical disability. The self-help [...]

Study answers why ketamine helps depression, offers target for safer therapy

Scientists have identified a key protein that helps trigger ketamine’s rapid anti-depressant effects in the brain, a crucial initial step to developing alternative treatments to the controversial drug being dispensed in a growing number of depression clinics across the country. Ketamine is drawing intense interest in the psychiatric field after multiple studies have demonstrated it [...]

Firefly gene illuminates ability of optimized CRISPR-Cpf1 to efficiently edit human genome

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells – and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases. Professor Michael Farzan, co-chair [...]